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1

Application of Proteomic Profiling Based on 2D-DIGE for Classification of Compounds According to the Mechanism of Action

Makoto Muroi, Sayaka Kazami, Kazue Noda, Hisae Kondo, Hiroshi Takayama, Makoto Kawatani, Takeo Usui, Hiroyuki Osada

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 761 KB

english, 2010

2

Quetiapine responsive catatonia in an autistic patient with comorbid bipolar disorder and idiopathic basal ganglia calcification

Ishitobi, Makoto, Kawatani, Masao, Asano, Mizuki, Kosaka, Hirotaka, Goto, Takashi, Hiratani, Michio, Wada, Yuji

Journal:

Brain and Development

Year:

2014

Language:

english

File:

PDF, 341 KB

english, 2014

3

Discovery of a Small Molecule PDI Inhibitor That Inhibits Reduction of HIV-1 Envelope Glycoprotein gp120

Khan, Maola M. G., Simizu, Siro, Lai, Ngit Shin, Kawatani, Makoto, Shimizu, Takeshi, Osada, Hiroyuki

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 2.53 MB

english, 2011

4

Development of the Passive-Type Force Display System ”Neo-PLEMO”, Which Can Display the Opposite Resistance Force against Handle on the Arbitrary Link Posture

FURUSHO, Junji, KAWATANI, Ryoji, HARAGUCHI, Makoto

Journal:

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C

Year:

2012

Language:

english

File:

PDF, 1.70 MB

english, 2012

5

Structure and biological activity of Metarhizin C, a stereoisomer of BR-050 from Tolypocladium album RK17-F0007

Nogawa, Toshihiko, Kawatani, Makoto, Okano, Akiko, Futamura, Yushi, Aono, Harumi, Shimizu, Takeshi, Kato, Naoki, Kikuchi, Haruhisa, Osada, Hiroyuki

Journal:

The Journal of Antibiotics

Year:

2019

Language:

english

File:

PDF, 674 KB

english, 2019

6

Structure-Activity Relationships of Terpendole E and Its Natural Derivatives.

Nagumo, Yoko, Motoyama, Takayuki, Hayashi, Toshiaki, Hirota, Hiroshi, Aono, Harumi, Kawatani, Makoto, Osada, Hiroyuki, Usui, Takeo

Journal:

ChemistrySelect

Year:

2017

Language:

english

File:

PDF, 425 KB

english, 2017

7

Reveromycin A Administration Prevents Alveolar Bone Loss in Osteoprotegerin Knockout Mice with Periodontal Disease

Mizuno, Manami, Miyazawa, Ken, Tabuchi, Masako, Tanaka, Miyuki, Yoshizako, Mamoru, Minamoto, Chisato, Torii, Yasuyoshi, Tamaoka, Yusuke, Kawatani, Makoto, Osada, Hiroyuki, Maeda, Hatsuhiko, Goto, Shig

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 2.85 MB

english, 2015

8

Iejimalides Show Anti-Osteoclast Activity via V-ATPase Inhibition

KAZAMI, Sayaka, MUROI, Makoto, KAWATANI, Makoto, KUBOTA, Takaaki, USUI, Takeo, KOBAYASHI, Jun’ichi, OSADA, Hiroyuki

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2006

Language:

english

File:

PDF, 180 KB

english, 2006

9

Identification of a Molecular Target of a Novel Fungal Metabolite, Pyrrolizilactone, by Phenotypic Profiling Systems

Futamura, Yushi, Kawatani, Makoto, Muroi, Makoto, Aono, Harumi, Nogawa, Toshihiko, Osada, Hiroyuki

Journal:

Year:

2013

Language:

english

File:

PDF, 1.76 MB

english, 2013

10

Creation of novel reveromycin derivatives by alcohol-added fermentation

Nogawa, Toshihiko, Takahashi, Shunji, Sekiyama, Yasuyo, Takagi, Hiroshi, Uramoto, Masakazu, Koshino, Hiroyuki, Kawatani, Makoto, Shimizu, Takeshi, Osada, Hiroyuki

Journal:

The Journal of Antibiotics

Year:

2013

Language:

english

File:

PDF, 329 KB

english, 2013

11

Genetic Safeguard against Mycotoxin Cyclopiazonic Acid Production in Aspergillus oryzae

Dr. Naoki Kato, Dr. Masafumi Tokuoka, Yasutomo Shinohara, Dr. Makoto Kawatani, Dr. Masakazu Uramoto, Dr. Yasuyo Seshime, Prof. Dr. Isao Fujii, Prof. Dr. Katsuhiko Kitamoto, Dr. Tadashi Takahashi, Dr.

Journal:

Year:

2011

Language:

english

File:

PDF, 606 KB

english, 2011

12

Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

Kawamura, Tatsuro, Kawatani, Makoto, Muroi, Makoto, Kondoh, Yasumitsu, Futamura, Yushi, Aono, Harumi, Tanaka, Miho, Honda, Kaori, Osada, Hiroyuki

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

13

Effect of Reveromycin A on experimental tooth movement in OPG−/− mice

Tanaka, Miyuki, Miyazawa, Ken, Tabuchi, Masako, Yabumoto, Takahiro, Kadota, Manami, Yoshizako, Makoto, Yamane, Chisato, Kawatani, Makoto, Osada, Hiroyuki, Maeda, Hatsuhiko, Goto, Shigemi

Journal:

Orthodontic Waves

Year:

2013

Language:

english

File:

PDF, 30 KB

english, 2013

14

A small molecule that induces reactive oxygen species via cellular glutathione depletion

Kawamura, Tatsuro, Kondoh, Yasumitsu, Muroi, Makoto, Kawatani, Makoto, Osada, Hiroyuki

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 937 KB

english, 2014

15

An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae

Shinohara, Yasutomo, Kawatani, Makoto, Futamura, Yushi, Osada, Hiroyuki, Koyama, Yasuji

Journal:

The Journal of Antibiotics

Year:

2015

Language:

english

File:

PDF, 432 KB

english, 2015

16

Identification of matrix metalloproteinase inhibitors by chemical arrays

Kawatani, Makoto, Fukushima, Yukako, Kondoh, Yasumitsu, Honda, Kaori, Sekine, Tomomi, Yamaguchi, Yoshiki, Taniguchi, Naoyuki, Osada, Hiroyuki

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2015

Language:

english

File:

PDF, 944 KB

english, 2015

17

Migrastatin, a Novel 14-Membered Ring Macrolide, Inhibits Anchorage-independent Growth of Human Small Cell Lung Carcinoma Ms-1 Cells.

TAKEMOTO, YASUSHI, NAKAE, KOICHI, KAWATANI, MAKOTO, TAKAHASHI, YOSHIKAZU, NAGANAWA, HIROSHI, IMOTO, MASAYA

Journal:

The Journal of Antibiotics

Year:

2001

Language:

english

File:

PDF, 500 KB

english, 2001

18

Involvement of Protein Kinase C-Regulated Ceramide Generation in Inostamycin-Induced Apoptosis

Makoto Kawatani, Siro Simizu, Hiroyuki Osada, Minoru Takada, Nadir Arber, Masaya Imoto

Journal:

Experimental Cell Research

Year:

2000

Language:

english

File:

PDF, 300 KB

english, 2000

19

Dual Structure–Activity Relationship of Osteoclastogenesis Inhibitor Methyl Gerfelin Based on TEG Scanning

Kanoh, Naoki, Suzuki, Takahiro, Kawatani, Makoto, Katou, Yasuhiro, Osada, Hiroyuki, Iwabuchi, Yoshiharu

Journal:

Bioconjugate Chemistry

Year:

2013

Language:

english

File:

PDF, 1.51 MB

english, 2013

20

ChemInform Abstract: Affinity-Based Target Identification for Bioactive Small Molecules

Kawatani, Makoto, Osada, Hiroyuki

Journal:

Year:

2014

File:

PDF, 12 KB

2014

21

Robust and Systematic Drug Screening Method Using Chemical Arrays and the Protein Library: Identification of Novel Inhibitors of Carbonic Anhydrase II

MIYAZAKI, Isao, SIMIZU, Siro, ICHIMIYA, Harumi, KAWATANI, Makoto, OSADA, Hiroyuki

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2008

Language:

english

File:

PDF, 250 KB

english, 2008

22

1P-020 Crystal structure of glyoxalase I in complex with methyl-gerfelin(The 46th Annual Meeting of the Biophysical Society of Japan)

Okumura, Hideo, Kawatani, Makoto, Osada, Hiroyuki

Journal:

Seibutsu Butsuri

Year:

2008

Language:

english

File:

PDF, 544 KB

english, 2008

23

Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis

Makoto Kawatani, Madoka Uchi, Siro Simizu, Hiroyuki Osada, Masaya Imoto

Journal:

Experimental Cell Research

Year:

2003

Language:

english

File:

PDF, 485 KB

english, 2003

24

Photo-Cross-Linked Small-Molecule Microarrays as Chemical Genomic Tools for Dissecting Protein–Ligand Interactions

Naoki Kanoh, Aya Asami, Makoto Kawatani, Kaori Honda, Saori Kumashiro, Hiroshi Takayama, Siro Simizu, Tomoyuki Amemiya, Yasumitsu Kondoh, Satoru Hatakeyama, Keiko Tsuganezawa, Rei Utata, Akiko Tanaka,

Journal:

Chemistry – An Asian Journal

Year:

2006

Language:

english

File:

PDF, 579 KB

english, 2006

25

Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9

Maola M.G. Khan, Siro Simizu, Takehiro Suzuki, Akiko Masuda, Makoto Kawatani, Makoto Muroi, Naoshi Dohmae, Hiroyuki Osada

Journal:

Experimental Cell Research

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

26

Affinity-based target identification for bioactive small molecules

Kawatani, Makoto, Osada, Hiroyuki

Journal:

Year:

2014

Language:

english

File:

PDF, 528 KB

english, 2014

27

Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus

Nogawa, Toshihiko, Kawatani, Makoto, Uramoto, Masakazu, Okano, Akiko, Aono, Harumi, Futamura, Yushi, Koshino, Hiroyuki, Takahashi, Shunji, Osada, Hiroyuki

Journal:

The Journal of Antibiotics

Year:

2013

Language:

english

File:

PDF, 200 KB

english, 2013

28

Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary bladder inflammation in rats

IKEDA, Makoto, KAWATANI, Masahito, MARUYAMA, Takayuki, ISHIHAMA, Hiroko

Journal:

Biomedical Research

Year:

2006

File:

PDF, 292 KB

2006

29

Synthesis and biological activities of reveromycin A and spirofungin A derivatives

Takeshi Shimizu, Takeo Usui, Makoto Fujikura, Makoto Kawatani, Tomoharu Satoh, Kiyotaka Machida, Naoki Kanoh, Je-Tae Woo, Hiroyuki Osada, Mikiko Sodeoka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 206 KB

english, 2008

30

Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases

Makoto Kawatani, Hiroyuki Osada

Journal:

Year:

2009

Language:

english

File:

PDF, 461 KB

english, 2009

31

Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification

Yushi Futamura, Makoto Kawatani, Sayaka Kazami, Kenichi Tanaka, Makoto Muroi, Takeshi Shimizu, Koji Tomita, Nobumoto Watanabe, Hiroyuki Osada

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 1.92 MB

english, 2012

32

Proteomic profiling reveals that collismycin A is an iron chelator

Kawatani, Makoto, Muroi, Makoto, Wada, Akira, Inoue, Gyo, Futamura, Yushi, Aono, Harumi, Shimizu, Kenshirou, Shimizu, Takeshi, Igarashi, Yasuhiro, Takahashi-Ando, Naoko, Osada, Hiroyuki

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.09 MB

english, 2016

33

Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA

Nagasawa, Ikuko, Muroi, Makoto, Kawatani, Makoto, Ohishi, Tomokazu, Ohba, Shun-ichi, Kawada, Manabu, Osada, Hiroyuki

Journal:

Cell Chemical Biology

Year:

2019

File:

PDF, 2.69 MB

2019

34

Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana

Sako, Kaori, Futamura, Yushi, Shimizu, Takeshi, Matsui, Akihiro, Hirano, Hiroyuki, Kondoh, Yasumitsu, Muroi, Makoto, Aono, Harumi, Tanaka, Maho, Honda, Kaori, Shimizu, Kenshirou, Kawatani, Makoto, Nak

Journal:

Scientific Reports

Year:

2020

File:

PDF, 1.63 MB

2020

35

Identification of a Small-Molecule Inhibitor of DNA Topoisomerase II by Proteomic Profiling

Makoto Kawatani, Hiroshi Takayama, Makoto Muroi, Shinya Kimura, Taira Maekawa, Hiroyuki Osada

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

36

Violaceols Function as Actin Inhibitors Inducing Cell Shape Elongation in Fibroblast Cells

ASAMI, Yukihiro, JANG, Jae-Hyuk, OH, Hyuncheol, SOHN, Jae Hak, KIM, Jong Won, MOON, Dong Oh, KWON, Osong, KAWATANI, Makoto, OSADA, Hiroyuki, KIM, Bo Yeon, AHN, Jong Seog

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2012

Language:

english

File:

PDF, 847 KB

english, 2012

37

Polarization of osteoclasts on dental implant materials is similar to that observed on bone

Nakayama, Takahiro, Thirukonda, Gnanasagar J., Nagasawa, Sakae, Kawahara, Ichiro, Udagawa, Nobuyuki, Yagami, Kimitoshi, Kawatani, Makoto, Osada, Hiroyuki, Doi, Yutaka, Yoshinari, Nobuo, Takahashi, Nao

Journal:

Journal of Oral Biosciences

Year:

2014

Language:

english

File:

PDF, 2.09 MB

english, 2014

38

Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library

Lim, Chung Liang, Nogawa, Toshihiko, Okano, Akiko, Futamura, Yushi, Kawatani, Makoto, Takahashi, Shunji, Ibrahim, Darah, Osada, Hiroyuki

Journal:

The Journal of Antibiotics

Year:

2015

Language:

english

File:

PDF, 209 KB

english, 2015

39

Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms

Futamura, Yushi, Muroi, Makoto, Aono, Harumi, Kawatani, Makoto, Hayashida, Marina, Sekine, Tomomi, Nogawa, Toshihiko, Osada, Hiroyuki

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2018

Language:

english

File:

PDF, 1.95 MB

english, 2018

40

Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library

Nogawa, Toshihiko, Takahashi, Shunji, Okano, Akiko, Kawatani, Makoto, Uramoto, Masakazu, Saito, Tamio, Osada, Hiroyuki

Journal:

The Journal of Antibiotics

Year:

2012

Language:

english

File:

PDF, 348 KB

english, 2012

41

Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters

Katsuyama, Shun, Sugino, Kumi, Sasazawa, Yukiko, Nakano, Yoshihiko, Aono, Harumi, Morishita, Keisuke, Kawatani, Makoto, Umezawa, Kazuo, Osada, Hiroyuki, Simizu, Siro

Journal:

Year:

2016

Language:

english

File:

PDF, 507 KB

english, 2016

42

Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K

Ohmae, Saori, Noma, Naruto, Toyomoto, Masayasu, Shinohara, Masahiro, Takeiri, Masatoshi, Fuji, Hiroaki, Takemoto, Kenji, Iwaisako, Keiko, Fujita, Tomoko, Takeda, Norihiko, Kawatani, Makoto, Aoyama, Mi

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.25 MB

english, 2017

43

The Potential of Protein Disulfide Isomerase as a Therapeutic Drug Target

Khan, Maola M. G., Simizu, Siro, Kawatani, Makoto, Osada, Hiroyuki

Journal:

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

Year:

2011

Language:

english

File:

PDF, 478 KB

english, 2011

44

Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74

Ueki, Masashi, Koshiro, Naofumi, Aono, Harumi, Kawatani, Makoto, Uramoto, Masakazu, Kawasaki, Hisashi, Osada, Hiroyuki

Journal:

The Journal of Antibiotics

Year:

2013

Language:

english

File:

PDF, 592 KB

english, 2013

45

Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice

Yabumoto, Takahiro, Miyazawa, Ken, Tabuchi, Masako, Shoji, Satsuki, Tanaka, Miyuki, Kadota, Manami, Yoshizako, Mamoru, Kawatani, Makoto, Osada, Hiroyuki, Maeda, Hatsuhiko, Goto, Shigemi

Journal:

American Journal of Orthodontics and Dentofacial Orthopedics

Year:

2013

Language:

english

File:

PDF, 2.16 MB

english, 2013

46

Methyl 3-((6-Methoxy-1,4-dihydroindeno[1,2- c ]pyrazol-3-yl)amino)benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods

Minegishi, Hidemitsu, Futamura, Yushi, Fukashiro, Shinji, Muroi, Makoto, Kawatani, Makoto, Osada, Hiroyuki, Nakamura, Hiroyuki

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.92 MB

english, 2015

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